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夏慧 副教授

发布时间:2023-10-07 点击量:

职称 副教授undefined

学位 理学博士

邮箱 xiahui123(at)hbucm.edu.cn (发邮件时请将(at)换成@)

主要招生专业及方向

中西医结合基础●生物技术在中医药研究中的应用

教育经历(从本科起倒序)

2012.09–2018.07,中科院水生生物研究所,理学博士

2008.09–2012.07,华中农业大学水产学院,农学学士

主要工作经历(倒序)

2022.01–至今,3044永利集团官网入口3044am永利集团,副教授

2018.07–2021.12,3044永利集团官网入口3044am永利集团,讲师

科研方向

1、中医药对衰老及代谢相关疾病的分子机制研究;

2、RNA表观遗传学对生长和生殖的影响机制研究。

学术兼职

1、人类疾病斑马鱼模型新药筛选襄阳市重点实验室学术委员会委员

2、中国生物化学与分子生物学会专业分会委员

主要科研成果

主持项目(倒序)

1、国家自然科学基金:基于斑马鱼模型研究m6A甲基转移酶Mettl3调控鱼类生长发育的分子机制(31902356),2020.01–2022.12,结题;

2、湖北省自然科学基金:基于m6A甲基转移酶Mettl3调控的斑马鱼衰老模型构建及其分子作用机制研究 (2019CFB230),2019.07–2021.07,结题;

3、湖北省教育厅青年人才项目:基于斑马鱼和细胞衰老模型研究何首乌二苯乙烯苷的抗衰老作用及其分子机制 (Q20192006),2019.01–2020.12,结题;

4、湖北省教育厅青年人才项目:基于Mettl3突变斑马鱼衰老模型探讨何首乌二苯乙烯苷的抗衰老作用 (2019ZZX016),2019.01–2020.12,结题;

代表性论著(#共同第一作者,*通讯作者)

1、Xia H#, Chen H#, Cheng X, Yin M, Yao X, Ma J, Huang M, Chen G*, Liu H*. 2022. Zebrafish: an efficient vertebrate model for understanding role of gut microbiota. Mol Med. 23;28(1):161.

2、Xia H#, Cheng X#;, Cao M, Sun X, He F, Yao X, Liu H*. 2023. Tetrahydroxystilbene glucoside attenuates oxidative stress-induced aging by regulating oxidation resistance and inflammation in larval zebrafish. Zebrafish, 20(2):55-66.

3、Cheng X, Yin M, Sun X, Zhang Z, Yao X, Liu H*, Xia H*. 2023. Hemin attenuated LPS-induced acute lung injury in mice via protecting pulmonary epithelial barrier and regulating HO-1/NLRP3 mediated pyroptosis. Shock, 59(5):p 744-753.

4、Yu S#, Xia H#, Guo Y, Qian X, Zou X, Yang H, Yin M, Liu H*. 2020. Ginsenoside Rb1 retards aging process by regulating cell cycle, apoptotic pathway and metabolism of aging mice. Journal of Ethnopharmacology, 255: 112746.

5、Hu H#, Xia H#, Zou X, Li X, Zhang Z, Yao X, Yin M, Tian D, Liu H*. 2021. N-acetyl-chitooligosaccharide attenuates inflammatory responses by suppression of NF-κB signaling, MAPK and NLRP3 inflammasome in macrophages. Journal of Functional Foods. 78: 104364.

6、Xia H#, Zhong C#, Wu X, Chen J, Tao B, Xia X, Shi M, Zhu Z, Trudeau VL, Hu W*. 2018. Mettl3 mutation disrupts gamete maturation and reduces fertility in zebrafish. Genetics. 208(2): 729-743.

7、Zhu L, Ye C, Hu B, Xia H, Bian Q, Liu Y, Kong M, Zhou S, Liu H*. 2022. Regulation of gut microbiota and intestinal metabolites by Poria cocos oligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fed mice. J Nutr Biochem. 107:109019.

8、Wang Q#, Chen H#, Yin M, Cheng X, Xia H, Hu H, Zheng J, Zhang Z*, Liu H*. 2023. In vitro digestion and human gut microbiota fermentation of Bletilla striata polysaccharides and oligosaccharides. Front Cell Infect Microbiol. 13: 1105335.

9、Wang X, Hu H, Hu B, Xia H, Cheng X, Zheng J, Zhang Z, Liu H*. 2023. Dihydromyricetin inhibits Hepatitis B virus replication by activating NF-κB, MAPKs, and autophagy in HepG2.2.15 cells. Mol Biol Rep. 50(2):1403-1414.

10、Yin M#, Wang N#, Wang Q, Xia H, Cheng X, Hu H, Zhang Z, Liu H*. 2023. Cloning and expression of recombinant human superoxide dismutase 1 (hSOD1) in Bacillus subtilis 1012. Biotechnol Lett. 45(1):125-135.

11、Liu Y, Cao Y, Zhang C, Ye C, Bian Q, Cheng X, Xia H, Zheng J*, Liu H*. 2022. A novel colorimetric method for H2O2 sensing and its application: Fe2+-catalyzed H2O2 prevents aggregation of AuNPs by oxidizing cysteine (FeHOAuC). Anal Chim Acta. 15; 1207: 339840.

12、Li Y, Hu H, Yang H, Lin A, Xia H, Cheng X, Kong M*, Liu H*. 2022. Vine tea (Ampelopsis grossedentata) extract attenuates ccl4 -induced liver injury by Restoring gut mcrobiota dysbiosis in mice. Molecular Nutrition & Food Research. 66(9): e2100892.

13、Chen M, Zheng J, Zou X, Ye C, Xia H, Yang M, Gao Q, Yang Q*, Liu H*. 2021. Ligustrum robustum (Roxb.) Blume extract modulates gut microbiota and prevents metabolic syndrome in high-fat diet-fed mice. Journal of Ethnopharmacology. 268: 113695.

14、Cheng X, Zheng J, Lin A, Xia H, Zhang Z, Gao Q, Lv W*, Liu H*. 2020. A review: Roles of carbohydrates in human diseases through regulation of imbalanced intestinal microbiota. Journal of Functional Foods, 74: 104197.

15、Hu H, Li A, Kong M, Yao X, Yin M, Xia H, Ma J, Liu H*. Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives. Journal of gastroenterology, 2019, 55(2): 142-158.

16、Zhang Y, Chen J, Cui X, Daji Luo, Xia H, Dai J, Zhu Z, Hu W*. 2015. A controllable on-off strategy for the reproductive containment of fish. Scientific Reports. 5:7614.

17、夏慧,余舒杰,邹小娟,陈 嫚,殷明珠,刘洪涛. 2021.人参皂苷Rb1通过Nampt-Sirt1-Tert通路和抗氧化应激延缓人脐静脉内皮细胞的衰老. 时珍国医国药. 32(4):850-854.

18、夏慧,陈龙云,邹小娟,姚小卫,周艳艳,徐建民,赵敏,陈会敏. 2020.中医药院校《生物化学》线上-线下混合式课程“金课”建设的探索与思考. 时珍国医国药, 31(04):960-961.

19、程雪, 夏慧, 殷明珠, 杨化冰, 刘洪涛, 王芳.2023. 宣白承气汤对脓毒症小鼠肺-肠损伤及肠道菌群的调节作用. 中华急诊医学杂志. 32(3): 346-352.

20、陈龙云,徐安莉,陈会敏,夏慧,赵敏.2019. 微助教平台融合下的《生物化学》BOPPPS教学模式探讨[J].中国医学教育技术. 33(06):719-723.

获奖及人才计划

1、3044永利集团官网入口第九届青年教师教学竞赛一等奖;

2、3044永利集团官网入口3044am永利集团第九届青年教师教学竞赛一等奖;

3、2021年3044永利集团官网入口优秀学士论文指导老师;

4、2021年3044永利集团官网入口3044am永利集团“优秀共产党员”;

主讲课程(研究生,本科生)

本科生:《医用化学》《生物化学》

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