职称 助理研究员
学位 理学博士
邮箱 caolu3489(at)hbucm.edu.cn (发邮件时请将(at)换成@)
主要招生专业及方向
免疫代谢●神经退行性疾病的临床和基础研究
教育经历（从本科起倒序）
2016.09–2022.07，中国科学院老员工命科学学院，理学博士
2012.09–2016.07，华中农业大学水产学院，农学学士
主要工作经历（倒序）
2022.08–至今，3044永利集团官网入口3044am永利集团学院，助理研究员
科研方向
1、神经退行性疾病的临床和基础研究（翻译后修饰调控、肠道菌群等）
2、神经退行性疾病的免疫代谢机制及应用研究
主要科研成果
科研项目（倒序）
1、湖北省自然科学基金联合项目：项目名称 (2023AFD143)，2023.06–2025.06，在研；主持
2、国家自然科学基金，面上项目：项目名称 (31972838)，2020.01–2023.12，在研；参与
3. 国家自然科学基金，面上项目：项目名称 (31873046)，2019.01–2022.12，结题；参与
4. 国家自然科学基金，面上项目：项目名称 (31873046)，2019.01–2022.12，结题；参与
代表性论著（#共同第一作者，*通讯作者）
1、Cao L, Fang H, Yan D, Wu XM, Zhang J, Chang MX*. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response[J]. Communications Biology, 2022, 5 (1):889.
2、Cao L, Yan D, Xiao J, Feng H, Chang MX*. The zebrafish antiapoptotic protein BIRC2 (cIAP1) promotes Edwardsiella piscicida infection by inhibiting caspases and accumulating p53 in a p53 transcription-dependent and -independent manner [J]. Frontiers in Immunology, 2021, 12:4840.
3、Cao L, Wu XM, Nie P, Chang MX*. The negative regulation of piscine CD44c in viral and bacterial infection[J]. Developmental and Comparative Immunology, 2019,96:135-143.
4、Cao L, Wu XM, Hu YW, Xue NN, Nie P, Chang MX*. The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses[J]. Developmental and Comparative Immunology, 2018,84:153-163.
5、Xiong F, Cao L, Xiong J, Wu YF, Huang WS, Chang MX*. Time-resolved and multi-tissue RNAseq provides new insights on the immune responses of European eels following infection with Aeromonas hydrophila[J]. Water Biology and Security, 2022, 1 (1):100003.
6、Xiong F, Cao L, Wu XM, Chang MX*. The function of zebrafish gpbar1 in antiviral response and lipid metabolism[J]. Developmental and Comparative Immunology, 2021, 116:103955.
7、Qi ZT#, Yan D#, Cao L, Xu Y, Chang MX*. Zebrafish BID Exerts an Antibacterial Role by Negatively Regulating p53, but in a Caspase-8-Independent Manner[J]. Frontiers in Immunology, 2021, 12:707426.
8、Wu XM, Cao L, Hu YW, Chang MX*. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae[J]. Fish and Shellfish Immunology, 2019, 94:355-372.
9、Wu XM, Cao L, Nie P, Chang MX*. Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes[J]. Developmental and Comparative Immunology, 2019, 101:103455.
10、Liu Y, Wang F, Liu Y, Cao L, Hu H, Yao X, Zheng J, Liu H. A label-free plasmonic nanosensor driven by horseradish peroxidase-assisted tetramethylbenzidine redox catalysis for colorimetric sensing H2O2 and cholesterol[J]. Sensors and Actuators B: Chemical, 2023, 389: 133893.
11、Wu XM#, Zhang J#, Li PW, Hu YW, Cao L, Ouyang SY, Bi YH, Nie P, Chang MX*. NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS[J]. Journal of Immunology, 2020, 204 (8):2216-2231.
12、Wu XM#, Chen WQ#, Hu YW, Cao L, Nie P, Chang MX*. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways[J]. Frontiers in Immunology, 2018, 9:726.
13、Hu YW#, Zhang J#, Wu XM, Cao L, Nie P, Chang MX*. TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation[J]. Frontiers in Immunology, 2018, 9:84.
14、Xiong F, Xiong J, Wu YF, Cao L, Huang WS, Chang MX*. Time-resolved RNA-seq provided a new understanding of intestinal immune response of European eel (Anguilla anguilla) following infection with Aeromonas hydrophila[J]. Fish and Shellfish Immunology, 2020, 105:297-309.
15、Li Y, Zheng J, Wang Y, Yang H, Cao L, Gan S, Ma J, Liu H. Immuno-stimulatory activity of Astragalus polysaccharides in cyclophosphamide-induced immunosuppressed mice by regulating gut microbiota[J]. Int J Biol Macromol, 2023, 242: 124789.
专利
1、昌鸣先，曹璐，武小曼. 一种转录因子的核酸、蛋白质及其应用. 中国发明专利, 专利号: ZL 2018 10512372.0.
2、昌鸣先，武小曼，曹璐. 核酸分子、表达载体及应用、抗菌药物和方法. 中国发明专利, 专利号: ZL 2019 10460046.4
获奖：
1、博士国家奖学金
2、刘瑞玉海洋科学奖学金
备注
